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KMID : 0603820170230020138
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Journal of Experimental & Biomedical Science
2017 Volume.23 No. 2 p.138 ~ p.143
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Hypocholesterolemic Effect of Ginkgo Biloba Seeds Extract from High Fat Diet Mice
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Kang Hyun
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Abstract
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To investigate the efficacy of extract of Ginkgo Biloba seeds in high fat diet (HFD) in mice, the Ginkgo Biloba seeds extract (GSE) was orally administered to mice with a HFD at 300 mg/kg/day for 4 weeks. Our results show that GSE significantly inhibited fat accumulation. Moreover, GSE markedly reduced the final body weight with a decrease in epididymal adipose tissue mass and adipocyte size compared with the untreated HFD-induced group. Additionally, GSE ameliorated serum high-density lipoprotein cholesterol levels. The results show that Ginkgo Biloba seeds possesses hypocholesterolemic effect through down regulating lipid metabolism. Further studies are required in this area to strengthen the anti-obesity effects of GSE with active component, and it can be used a pro-drug instead of whole extract.
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KEYWORD
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Ginkgo Biloba seeds , Hypocholesterolemic , Lipid metabolism , High fat diet mice
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